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JUICE PLUS+® • SPRING/SUMMER 2007

January 11, 2009

THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+® • SPRING/SUMMER 2007
Inside…
UNCG and
Vanderbilt Studies
Prevention Plus+ Profile:
Roger D. Woodruff, M.D.
About the Researchers
Three new clinical studies published in peer-reviewed scientific journals over the past few
months demonstrate the healthful benefits of taking Juice Plus+®.
University of Florida: Juice Plus+® helps support
the immune system and protect DNA.
Good nutrition is important for normal function of the
immune system. So a research team at the University of
Florida studied the impact of taking Juice Plus+® on the
immune systems of 59 healthy, young law school
students. Like almost every new clinical investigation
conducted on Juice Plus+® since 2001, the Florida trial
was a “gold standard” (a randomized, double-blind,
placebo-controlled) study: 31 students consumed Juice
Plus+® Orchard Blend and Garden Blend twice a day
for 77 days, while 28 students took a placebo for the
same time period. The scientists then compared the
Juice Plus+® group with the subjects who did not take
the product.
The results, published in the October, 2006 issue of
The Journal of Nutrition (136: 2606-2610), showed a significant increase among the
Juice Plus+® subjects in a specific type of T-cell, called a gamma delta T-cell, that plays an
important role in protecting the body from microbes associated with infectious illnesses. In
addition, the researchers saw a significant increase in the phytonutrients beta-carotene, lutein,
lycopene, and vitamin C after consumption of Juice Plus+® as well as a significant decrease in
susceptibility to DNA damage. DNA is the basic building block of life that determines the
development and behavior of every cell.
“There was not just an increase in the plasma levels of important
Juice Plus+® shines
in new clinical studies.
(continued on next page)
SPRING/SUMMER 2007 • THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+®
nutrients,” lead investigator Susan Percival, Ph.D. observes,
“but the antioxidants were actually doing something beneficial
when they got there.”
Dr. Percival is especially impressed with the immune results
given the nature of the subjects involved. “Law students are by
definition an extremely stressed population, and stress has
been shown to impair immune response. In addition, Florida
was hit by four hurricanes during the 11 weeks of the study,
which further added to the stress level of the subjects.”
The Journal of Nutrition is a monthly publication of the
American Society for Nutrition.
University of North Carolina, Greensboro:
Juice Plus+® reduces oxidative stress.
Researchers at the University of North Carolina, Greensboro,
led by Allan Goldfarb, Ph.D., found that Juice Plus+® was as
effective as much higher amounts of vitamins C and E in
reducing a marker for oxidative stress associated with
aerobic exercise.
In earlier research, the UNCG research team had established
the effects of high doses of vitamins C and E alone on the
oxidative stress that naturally occurs when we perform aerobic
exercise. Of course, Juice Plus+® contains a wide variety of
natural antioxidants including vitamins C and E. In a gold
standard study of 48 healthy, aerobically trained men and
women, the UNCG scientists tested whether the much lower
levels of vitamins C and E in Juice Plus+® – delivered in combination
with the other phytonutrients in the product – would
have a similar effect as much higher doses of isolated vitamins
C and E.
“We took the vitamin C level generally used in previous studies
and we gave our subjects a little bit higher level of vitamin C
than even that,” Goldfarb elaborates. “Then we combined
that higher dose of Vitamin C with a high dose of
vitamin E.” The subjects were divided into three groups who
were randomly assigned to take one of the following for a twoweek
period: placebo; 1000 mg of vitamin C and 400 IU
of vitamin E; or, Juice Plus+®
Orchard, Garden, and
Vineyard blends.
The investigators concluded
that Juice Plus+® – with its substantially
lower amounts of
vitamins C and E – provided
similar antioxidant benefits
compared to the much larger
doses of freestanding vitamins
C and E.
“This is important for two
reasons,” explains John Blair, NSA’s Vice-President of Product
and Research. “First, with Juice Plus+®, you get not only the
vitamins C and E, but also the benefits of all the other antioxidants
in our fruit and vegetable juice powders. Second, some
recent studies suggest that large doses of isolated antioxidant
vitamins might not be beneficial and can actually have harmful
effects.”
Dr. Goldfarb agrees. “There are a number of studies that show
that if you take a large amount of just vitamin C alone, for
example, it can actually cause a prooxidant response.”
The results of the study by Goldfarb and his colleagues
appeared in the June, 2006 issue of Medicine & Science in
Sports & Exercise (38: 1098-1105), the official journal of the
American College of Sports Medicine.
Vanderbilt University School of Medicine:
Juice Plus+® improves markers of cardiovascular health.
In a non-gold standard
pilot study conducted
by investigators from
Vanderbilt University
School of Medicine,
researchers monitored
51 adults – primarily
hypertension patients,
most of them on medication
– who took
Juice Plus+® Orchard,
Garden, and Vineyard
blends for two years.
Overall, the test subjects
showed improvements
in several key measures of vascular health – with no
adverse side effects.
“First, Juice Plus+® improved the antioxidant status of the
patients,” lead investigator Mark Houston, M.D. elaborates.
“We also found that their arterial health improved – the
arteries became more elastic, more pliable. In addition, as the
arteries got healthier, we observed a modest reduction in both
systolic and diastolic blood pressure – clearly beneficial, but
not enough to support any change in medication. We also
observed small but significant decreases in two key markers of
cardiovascular health: glycated hemoglobin and homocysteine.
“Putting it all together, the results showed that important
markers of oxidative stress, oxidative defense, arterial health,
and coronary heart disease all improved in subjects consuming
Juice Plus+®.”
These pilot study results were just released in the March, 2007
edition of the online journal Evidence-based Complementary
and Alternative Medicine. (continued on next page)
Home: Spokane, Washington.
Specialty: Family medicine.
Education and Training: Graduated from Loma Linda
University School of Medicine in Loma Linda, California in
1981. Completed residency in Family Practice at Florida
Hospital in Orlando in 1984.
Professional History: Served on the teaching faculty of Florida
Hospital in Orlando from 1984-1987. Family practice, South
Hill Family Medicine of Spokane, 1990-present.
Key Professional Accomplishment: Between 1987 and 1990
served as Director of the Family Medicine Residency Program
at Loma Linda University Medical Center. In that capacity
he helped to establish and build a respected new residency program
and secure its accreditation.
Key Personal Accomplishment: Father of three.
Community Service: Served as President and two-term
member of the Board of Directors for the Spokane Youth
Symphony.
Personal Mission: “We must educate the next generation in
healthier eating in order to reverse the current epidemic of
degenerative diseases such as heart disease, stroke, diabetes,
and cancer.”
Health Advice: “Whole food nutrition is the foundation of a
healthy and vibrant life. When it comes to diet, I’ve learned
that making a few little changes here and there can make very
big differences in one’s health – differences that start to ‘snowball’
in a positive direction over time.”
Why he recommends Juice
Plus+®: “Sometimes the most
powerful remedies are the
simplest. After many years of
taking diet histories from my
patients, I can say unequivocally
that almost no one has a
‘perfect’ diet and that most
people never will. It’s just so
hard for people to eat ‘right’
given the hectic pace of
modern life and the proliferation
of unhealthy food
options. Even those patients
who really try to improve their
diets find that maintaining
the proper balance – especially
eating enough fruits and vegetables
– is a very difficult, if
not impossible, task.
“Now I can encourage a healthy diet that includes daily nutrition
from a wide variety of fruits and vegetables – with far
greater confidence that my patients can actually comply.
Because even though most of them can’t, don’t, or won’t eat
enough fruits and vegetables, they can take Juice Plus+® to
help bridge that nutritional gap.
“I know of nothing else with or without a prescription that
provides the range of clinically-proven benefits that Juice Plus+®
does. It provides a nutritional safety net that everyone needs.”
SPRING/SUMMER 2007 • THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+®
Prevention Plus+ Profile:
Roger D. Woodruff, M.D.
“Sometimes the
most powerful
remedies are
the simplest.”
Roger Woodruff is one of the
many health professionals speaking
to audiences around the
world as part of our Juice Plus+®
Prevention Plus+ Health
Education Series. If you’d like to
attend a Prevention Plus+
seminar in your area, ask your
Juice Plus+® representative or
call our Juice Plus+® information
line at 1-877-JUICEPLUS
(1-877-584-2375).
A commitment to independent research
All three researchers emphasize both the quality and the
independence of the clinical research being conducted on
Juice Plus+®. Dr. Goldfarb is “very impressed that NSA allows
scientists to do the research without interference and to
publish the results regardless of what they are.”
“We’re not just doing little ‘side studies’ here,” Dr. Percival
adds. “We’re doing important, complete, high quality clinical
research.”
“It takes a very bold and very ethical company to turn their
products over to independent researchers to prove that they
have scientific merit,” Dr. Houston suggests.
“That’s not surprising for a company like ours that tells
people our product is only ‘the next best thing’ to eating a
wide variety of fruits and vegetables every day,” Blair
concludes. “But people just aren’t likely to do that. Juice
Plus+® is there to help fill the inevitable gap between people’s
actual daily diets and the nutrition they need.”
SPRING/SUMMER 2007 • THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+®
About the researchers
Susan Percival, Ph.D. is a full professor
of nutritional sciences in the Department
of Food Science and Human Nutrition at
the University of Florida, where she
teaches a course on Dietary Supplements
and a course on Nutrition and Immunity.
She recently returned to Florida from a
sabbatical at the National Cancer
Institute of the National Institutes of
Health. From 1978 to 1981, Dr. Percival served on the
faculty of the University of Rhode Island, leaving to pursue
her Ph.D. at the University of Texas, Austin. She did postdoctoral
research in the department of Biochemistry and
Biophysics at Texas A&M University.
Dr. Percival has served on the editorial board of The Journal
of Nutrition since 2000, as well as on two committees of the
Food and Nutrition Board at the Institute of Medicine of the
National Academy of Sciences. Her current research activities
are focused on how dietary components – particularly bioactives
from foods – influence immunity and DNA.
Allan Goldfarb, Ph.D. – a full professor
in the Exercise and Sport Science
Department at the University of North
Carolina, Greensboro – is an exercise
physiologist with a specialization in sports
nutrition. Dr. Goldfarb was awarded his
Ph.D. from Temple University in 1979,
after which he served as a post-doctoral
research associate in the Department of
Pharmacology at the Medical College of Pennsylvania. He
moved on to become an assistant professor at the University
of Maryland, then relocated to UNCG in 1987. He has been
a fellow of the American College of Sports Medicine (ACSM)
since 1983 and is the immediate past president of the
Southeast Chapter of that organization.
Dr. Goldfarb has published more than 60 peer-reviewed
articles in such journals as the Journal of Applied Physiology,
Medicine & Science in Sports & Exercise, the European Journal
of Applied Physiology, the International Journal of Sports
Nutrition and Exercise Metabolism, Endocrinology, and the
Canadian Journal of Applied Physiology. He has also published
over 100 presentations and 14 chapters in books, and serves
on the editorial board of two journals.
Mark Houston, M.D. is an associate
clinical professor of medicine at
Vanderbilt University School of
Medicine, as well as Director of the
Hypertension Institute and Vascular
Biology at Saint Thomas Hospital in
Nashville, Tennessee. He graduated from
Vanderbilt Medical in 1974 and served
his internship and residency at the
University of California, San Francisco. He returned to
Vanderbilt as chief resident in 1977 and has been affiliated
with the medical school ever since, including 12 years as a
full-time member of the faculty.
Dr. Houston has conducted over 80 studies and published
more than 130 medical articles and scientific abstracts in
peer-reviewed journals, primarily on cardiovascular disease
and hypertension. He is the author of several best-selling
books, including What Your Doctor May Not Tell You About
Hypertension. He has served on the editorial boards of – or as
editorial consultant or a peer reviewer for – 20 different medical
journals, including The New England Journal of Medicine,
The Journal of the American Medical Association, and
Hypertension.
Susan Percival, Ph.D.
Allan H. Goldfarb, Ph.D.
Mark Houston, M.D.
955210

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