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February 11, 2009

THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+® • SUMMER/FALL 2005
Inside…
Prevention Plus+ Profile:
Frank Eggleston, D.D.S.
Clinical research
currently in progress
Investigators associated with hospitals and universities on three different continents are
currently studying the effects of Juice Plus+® on everything from the immune systems
of college students to the periodontal health of smokers.
“It’s an extension of earlier clinical research on Juice Plus+®,” according to John Blair,
Vice President of Product Development and Research for NSA.
Over the past several years, Juice Plus+® clinical studies have been conducted by investigators
from such institutions as the University of Maryland, the University of Arizona,
and the University of Sydney (Australia) and published in a number of peer-reviewed
scientific journals, including the Journal of Nutrition, the Journal of the American College
of Cardiology, and Nutrition Research.
Blair suggests that the current wave of new Juice Plus+® clinical studies flows logically
from these earlier studies.
For example, a study by researchers at the University of Arizona, published in 1999 in
Integrative Medicine, showed that taking Juice Plus+® significantly improved several key
markers of immune system function in an elderly population. Now, researchers at the
University of Florida are studying markers of immune function in healthy young adults.
“The earlier research showed that Juice Plus+® had a positive impact on the immune
system in elderly people, who tend to have more impaired immune function,” Blair
elaborates. “If the new study shows that Juice Plus+® can have a similar impact on
younger people with naturally more robust immune systems – well, that obviously says
even more about the benefits of taking our product.”
Six previous studies demonstrated that subjects taking Juice Plus+® consistently show
increases in key phytonutrients in the bloodstream – including beta-carotene, vitamin E,
vitamin C, folate, lycopene, and other carotenoids – in as little as 28 days on the
product. Investigators refer to this as “bioavailability” – “that it gets into the bloodstream
where it can do some good,” Blair explains.
Scientists continue to study
the health benefits of Juice Plus+®
(continued on the following page)
SUMMER/FALL 2005 • THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+®
Today, researchers from Georgetown
University and UCLA are investigating
the bioavailability of Juice Plus+® in an
overweight population, while investigators
at Tokyo Women’s Medical
University in Japan are analyzing the
bioavailability of Juice Plus+® in an
Asian population.
“This is the nature of scientific investigation
– to build upon previous
research,” Blair reinforces.
Juice Plus+® and oxidative stress
Previous research demonstrating the impact of Juice Plus+® on
oxidative stress has led to a new study by investigators at the
University of North Carolina-Greensboro. Oxidative stress is
believed to be a precursor to many degenerative diseases, such
as heart disease, stroke, and cancer. “Antioxidants” from fruits
and vegetables help to combat it.
The original Juice Plus+® bioavailability study – published in
Current Therapeutic Research in 1996 – showed that Juice
Plus+® reduced lipid peroxides in the blood plasma of test subjects
overall by an average of 75%, and reduced them to undetectable
levels in a third of the subjects. “Lipid peroxides are a
product of oxidative stress,” Blair explains. “Fewer lipid peroxides
in the bloodstream means that Juice Plus+® effectively
reduced oxidative stress.”
Another study – conducted at King’s College in London and
published in the Journal of Human Nutrition & Dietetics in
2000 – showed improvement in another general indicator of
oxidative stress, plasma malondialdehyde, among subjects
taking Juice Plus+®. A more recent study at the University
of Sydney – published in the Journal of Nutrition in 2003 –
showed an improvement in total plasma antioxidant capacity
among subjects taking Juice Plus+®. Greater antioxidant
capacity means less oxidative stress.
The North Carolina-Greensboro investigators are concentrating
on the effect of Juice Plus+® on exercise-induced oxidative
stress. “Moderate exercise is an important part of a healthy
lifestyle, but exercise contributes to oxidative stress,” Blair
warns. “Getting a wide array of naturally occurring antioxidants
from a wide variety of fruits and vegetables is key to
offsetting this.”
Juice Plus+® and cardiovascular wellness
One of the most promising areas of clinical investigation has
been the impact of Juice Plus+® on cardiovascular wellness.
Cardiovascular disease is the leading cause of non-accidental
death in the United States, killing approximately one million
Americans every year – almost twice as many as cancer.
Previous research has demonstrated that Juice Plus+® promotes
cardiovascular health in two ways: by reducing the levels of
homocysteine in the bloodstream, and by helping maintain
normal blood flow after eating a high fat meal.
“Homocysteine is an amino acid produced by the body that is
a proven risk factor in cardiovascular disease,” says Blair.
“Elevated levels of homocysteine in the blood correlate to a
significantly elevated risk of heart attack, stroke, venous
thromboembolism (blood clots in the veins), and other forms
of cardiovascular disease.”
In a study at the University of Sydney – published in 2003 in
the Journal of Nutrition – relatively healthy subjects who started
out with acceptable levels of homocysteine still experienced
an 8.4% reduction after taking Juice Plus+® for six weeks.
In a similar study conducted in Foggia, Italy – published in
Nutrition Research in 2003 – subjects who started out with
much higher levels of homocysteine experienced a 37% reduction
after taking Juice Plus+® for only four weeks.
“Most experts agree that adults should have a plasma homocysteine
level of less than 10 micromoles (μM) per liter,” Blair
explains. “In both of these studies, subjects taking Juice Plus+®
reduced their homocysteine to an average of less than 8 μM.”
In a study conducted by researchers at the University of
Maryland – published in the Journal of the American College of
Cardiology in 2003 – subjects who consumed Juice Plus+®
were better able to maintain the elasticity of arteries, even after
a high fat meal.
The Yale-Griffin Study
Previous research on Juice Plus+® and heart health caught the
attention of David Katz, M.D., Executive Director of the Yale
University-Griffin Hospital Prevention Research Center in
Connecticut. Recognizing that two out of three people with
diabetes die from heart disease and stroke, Dr. Katz wanted to
test the cardiac effects of Juice Plus+® on insulin-resistant
adults. People who have insulin resistance often develop
Type 2 adult onset diabetes.
Dr. Katz notes that many clinical studies have shown that
nutrients have diminished effects when taken in isolation, as
with traditional vitamin supplements. He views Juice Plus+® as
a way to test whether a much greater array of nutrients from
whole food sources working in tandem can improve cardiac
health. “[Juice Plus+®] preserves just about everything and distills
it in a few capsules. Our basic hypothesis is we believe there
will be a benefit from taking plant-based nutrients together.”
John Blair
(continued on the following page)
SUMMER/FALL 2005 • THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+®
Prevention Plus+ Profile:
Frank Eggleston, D.D.S.
Home Houston, Texas.
Specialty Restorative and Operative Dentistry.
Education Graduated from Texas Christian
University, 1965. Received DDS, Baylor
University College of Dentistry, 1970.
Current position Private practice in Houston
since 1972.
Professional History Served on the American
Dental Association Board of Trustees, and as
President of the Texas Dental Association.
Public speaker for getting sugar out of the diet
and for wellness and prevention.
Honors and Accomplishments Named Dentist
of the Year by the Texas Academy of General
Dentistry, 1995. Recipient of Texas Dental
Association Distinguished Service Award,
1996; and, the TDA Gold Medal for
Distinguished Service, 2004.
Community Service Volunteer at San Jose
Clinic. Member of the Board of Trustees for
the Retina Research Foundation and for the
University Area Rotary Club. Teaches conflict
resolution.
Health Advice “We need to step up and say
that our nutrition as a country is very bad and
work to correct it. We have to start talking to
moms and dads about their kids and about
nutrition and getting off sugar. I don’t want to
see children with cavities, of course, but I also
don’t want their bodies to be affected. I mean,
when I see a lot of cavities in a patient’s
mouth I know that equally bad things are
occurring in their overall health.”
How he uses Juice Plus+® in his practice
“I see a lot of people with bleeding gums. We
do a cleaning, and they’re gushing blood.
“Back in the 80s, I’d say start taking 1,500
milligrams of vitamin C, that sort of thing,
because that’s all we knew about nutrition
back then. Now of course, I put them on
Juice Plus+®.”
“When I see a lot
of cavities in a
patient’s mouth, I
know that equally
bad things are
occurring in their
overall health.”
Dr. Frank Eggleston is one of the
many health professionals speaking
to audiences around the
world as part of our Juice
Plus+® Prevention Plus+ Health
Education Series. If you’d like to
attend a Prevention Plus+
Seminar in your area, ask your
Juice Plus+® representative or
call our Juice Plus+® information
line at 1-877-JUICEPLUS
(1-877-584-2375).
The Yale-Griffin study began earlier this
year and will test roughly 40 subjects
over a 12-month period, according to
Katz. “We’ll look at the effects of the
capsule on an adult population that
meets the criterion of having insulin
resistance,” he explains.
Dr. Katz stresses that the health benefits
of a diet rich in fruits and vegetables
have been proven beyond any doubt.
“Diets rich in fiber and complex carbohydrates, found in
fruits, vegetables, beans, and whole grains, have been shown in
a wide array of studies to be associated with longevity, lasting
weight control, reduced risk of cancer, reduced risk of cardiovascular
disease, reduced risk of diabetes, reduced risk of
gastrointestinal disorders, and overall health promotion.” But,
he notes out that the majority of Americans’ intake of fruits
and vegetables falls short of the recommended levels.
“That, of course, is why there’s Juice Plus+® – to support the
all-important fruit and vegetable food group,” Blair observes.
Blair points out that researchers such as Dr. Katz like to use
Juice Plus+® in their studies for a very simple reason. “It’s an
easy and convenient way for them to test the health benefits of
whole food nutrition from a wide variety of fruits and vegetables,
just as it’s an easy way for consumers to enjoy those
benefits every day.”
David Katz, M.D.
Investigator(s) from are studying
University of Florida
the effect of Juice Plus+® on markers of immune function in healthy
young adults
Georgetown University and UCLA the bioavailability of Juice Plus+® in an overweight population
University of North Carolina
the impact of Juice Plus+® at Greensboro on exercise-induced oxidative stress
Vanderbilt University Medical School the effect of Juice Plus+® on parameters of vascular wellness
University of Würzburg, Germany
the effect of Juice Plus+® on the outcome of periodontal treatment in
smokers with poor gum health
Wake Forest University, funded by the
National Cancer Institute of the the effect of Juice Plus+® on nutritional status and various markers of cell
National Institutes of Health health in people who have survived head and neck tumor treatment
University of Texas/MD Anderson the effect of Juice Plus+® capsules and Complete compared to diet modification
Cancer Center alone on the nutritional status and quality of life of ovarian tumor survivors
Tokyo Women’s Medical University the bioavailability of Juice Plus+® in an Asian population
Yale University-Griffin Hospital
Prevention Research Center the effect of Juice Plus+® on endothelial function in insulin-resistant adults
University of Mississippi Medical Center the effects of Juice Plus+® on pregnancy health
955205
SUMMER/FALL 2005 • THE HEALTH & WELLNESS NEWSLETTER FROM THE MAKER OF JUICE PLUS+®
The Science of Juice Plus+®: Clinical Research in Progress
Researchers at leading hospitals and universities around the world continue to evaluate a wide range of health and nutritional
benefits associated with taking Juice Plus+®.

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